Air, Nitrox & Fatigue

We investigate the correlation between diving with air or nitrox and the onset of fatigue, especially since divers report feeling less tired after diving with nitrox.
For decades compressed air has been the standard and most widely-used breathing mix in recreational diving. Breathing-gas mixtures with a lower nitrogen content and higher oxygen content (enriched air nitrox) have gained popularity amongst divers looking to increase their bottom times or to reduce the decompression stress of typical-duration dives. Today, after some 25 years of nitrox use in recreational diving, divers and scientists have gained very valuable operational experience. But, some divers have made an observation for which science does not provide any evidence. Namely, they often report feeling less tired after diving on nitrox. Is there any solid evidence to support the observation that nitrox reduces fatigue and what is a possible scientific explanation to describe this phenomenon?
Tiredness, or physical fatigue, is a physiological consequence of extraordinary physical activity. It is characterised by a subjective feeling of a transient reduced capacity to perform ordinary physical activities. It is often associated with somnolence and lethargy and sometimes with suboptimal cognitive performance. Fatigue is not uncommon following inconsequential dives in the absence of apparent decompression sickness (DCS), but it is also frequently reported as a symptom of DCS.

Controversy surrounds divers’ subjective reports of feeling less fatigued following nitrox dives. Contrary to these perceptions, objective studies have not found a reliable difference in fatigue or cognitive performance following dives on air versus on nitrox.
Given an equal depth and time exposure, it is generally accepted that the higher the partial pressure of the inspired oxygen (PO2) and the lower the partial pressure of the inert gas (PN2), the less decompression stress will be experienced. It is then tempting to assume that lower decompression stress accompanies the reduced perceptions of tiredness. However, a higher PO2 elicits more oxidative stress, and the PO2 of nitrox will be higher than that of air at a given depth.
Some studies of divers suggest that oxidative stress generated by nitrox’s higher PO2 might cause mild endothelial dysfunction, which may itself lead to some vague symptoms that may be perceived as tiredness. Observations from hyperbaric-medicine clinicians, who report that greater oxidative stress during hyperbaric oxygen therapy is associated with greater fatigue following treatment, support these findings.
We consulted two subject-matter experts (Dr Richard Harris and Dr Neal W. Pollock) to help us reconcile divers’ impressions of nitrox’s beneficial effects on post-dive fatigue with some controversial findings in studies of the phenomenon.

A:  Harris: Post-dive tiredness can be the result of multiple factors. Some of them could be diving related, such as thermal stress, decompression stress, energy expenditure, high and prolonged oxygen exposure, anxiety and seasickness. But, there are many more potentially unrelated causes such as the lack of sleep on holidays, the consumption of alcohol and jet lag.

Pollock: Many people do not fully appreciate the physiological impact of being immersed in water. An immediate response to the hydrostatic pressure is that a substantial amount of blood (which normally remains in the veins of the legs) is pushed into the chest. A well-known study of this effect found that an average of 700 mℓ of blood is pushed to the heart during the resting phase of the cardiac cycle. The heart is stretched by the increased blood volume and responds immediately by contracting harder and then, over a short period, by suppressing certain hormones to promote increased fluid elimination through the kidneys. This is a healthy response to the physiological perception of the presence of excess fluid volume. Practically, this is why people have to urinate even after fairly short periods of immersion.

After leaving the water, the diver may experience an immediate drop in the volume of blood returning to the heart. I specifically said “may” because a constricting wetsuit may shift some of the blood to the chest even without immersion. Post-dive or post-wetsuit removal, the diver will experience a decline in the central blood volume and blood pressure. The effect exceeds the simple loss of hydrostatic pressure, because the body has actively reduced the fluid volume during the diving- or wetsuit-wearing period. Effectively, this set of events likely explains a substantial portion of the normal post-dive tiredness. Most importantly, fatigue is due to immersion, independent of depth and decompression stress.

A: Harris: No. Three peer-reviewed articles contribute evidence to the nitrox and fatigue question, but I am not convinced that the size and power of any of them have addressed the problem comprehensively.

Pollock: The data supporting these claims are not compelling. This is not surprising since PO2 increases substantially in response to depth alone. However, there is no reason to argue over whether a person feels less fatigued. Research has shown that the placebo effect has a physiological impact, so let the diver enjoy the sense. The important thing is for divers to stay within the PO2 limits to avoid oxygen toxicity.

A  Harris: One interesting comment from Pierre Lafère’s article is that oxidative stress can inhibit neuronal activity (as with alcohol, for example), and this can affect inhibitory neurons, thus temporarily increasing a person’s arousal levels.
On a personal note, my teammates and I have felt very good after eight- to 17-hour cave dives in 6°C water and maximum depths of more than 200 m. Considering the thermal, decompression, physical, oxidative and psychological stresses endured on these dives, how could we reconcile this?

Maybe we were just happy to be alive. But, I have also felt dreadful, tired and “chesty” after much shallower dives with lower O2 exposures and shorter run times in warmer water. There are too many variables to consistently detect a difference just with a simple gas change.

Pollock: Oxidative stress certainly has the potential to be problematic, but probably far less so with the typically short exposures which are associated with most recreational diving. Further research is required to assess the physiological impact.

A  Harris: I believe that fatigue can be a symptom of DCS, but it needs to be something very marked to impress me. Severe fatigue, such as feeling like you have the flu rather than just being a bit more tired than usual after diving is a more serious issue. Rather than to use the term sub-clinical DCS, which I do not favour, I would only call it fatigue DCS if it is part of a constellation of symptoms.

Pollock: Normal patterns of post-dive tiredness do not qualify, but unusual fatigue which is markedly in excess of typical levels could be a sign or more likely a symptom of DCS. Having the diver describe the nature and degree of the effect is important to help distinguish normal fatigue from unusual fatigue.

Despite the common impression that diving on nitrox may cause less fatigue than performing the same dive using an air mixture, scientific research to date has not found solid evidence to support such an assumption. As mentioned, the placebo effect should not be underestimated and has yet to be fully studied.

Regardless of what questions future research on this front might answer, it is still appropriate to promote the wise use of oxygen-enriched mixtures — not necessarily as a way to extend bottom times, but rather as a way to help minimise decompression stress. If diving with nitrox makes you feel less tired after your day of diving, whether you have scientific support for your experience or not, feel free to use it. Just make sure you enjoy it safely. 

Whenever you plan to use nitrox, make sure you plan your dive with a clear view of your goals. Using nitrox means juggling between three possible benefits, including extended bottom times, reduced surface intervals, or reduced decompression stress. Whichever benefit you choose to pursue, remember to be respectful of the increased risk of oxygen toxicity.
If you choose to minimise decompression stress, you should not count on longer dives and/or shorter surface intervals. If you want longer dives, your decompression stress may not be reduced, and your surface intervals should not be any shorter. Note that the decompression stress of diving with nitrox to its no-decompression limit is comparable to diving air to its no-decompression limit. The decompression benefit provided by nitrox may not be sufficient if surface intervals are too short. By increasing the oxygen fraction, it reduces the depth at which oxygen toxicity can occur. One must never exceed the maximum operating depth (MOD) for the mixture.


Dr Richard Harris is an Australian anaesthesiologist who works in diving medicine and aeromedical retrieval. He has qualifications in expedition and wilderness medicine and is an active exploration caver and cave diver. A diver for more than 30 years, his images and videos are widely published in the diving media. His current research interests include decompression illness (DCI) in technical divers.

Dr Neal W. Pollock is the research director at DAN and a research associate for the Center for Hyperbaric Medicine and Environmental Physiology at Duke University Medical Center, both in Durham, North Carolina. His academic training is in zoology, exercise physiology and environmental physiology. His research interests focus on human health and safety in extreme environments. He is actively involved in projects of diving and freediving safety, astronaut decompression and ultrasonic assessment of decompression-induced bubbles.
  1. Chapman, S.D & Plato, P.A. Measurement of fatigue following 18 msw open-water dives breathing air or EAN36. In: Brueggeman, P. & Pollock, N.W. eds. Proceedings of the American Academy of Underwater Sciences 27th Symposium. Diving for Science 2008, 2008; p1-11.
  2. Harris, R.J.D. Doolette, D.J. Wilkinson, D.C. & Williams, D.J. Measurement of fatigue following 18 msw dry chamber dives breathing air on enriched air nitrox. Undersea Hyperb Med, 2003; 30(4): p285-291.
  3. Lafère, P. Balestra, C. Hemelryck, W. Donda, N. Sakr, A. Taher, A. Marroni, S. & Germonpré, P. Evaluation of critical flicker fusion frequency and perceived fatigue in divers after air and enriched air nitrox diving. Diving Hyperb Med, September 2010; 40(3): p114-118.
  4. Marinovic, J. Ljubkovic, M. Breskovic, T. Gunjaca, G. Obad, A. Modun, D. Bilopavlovic, N. Tsikas, D. Dujic, Z. Effects of successive air and nitrox dives on human vascular function. Eur J Appl Physiol, June 2012; 112(6): p2131-2137.
  5. Obad, A. Palada, I. Valic, Z. Ivancev, V. Bakavoic, D. Wisløff, U. Brubakk, A.O. Dujic, Z. The effects of acute oral antioxidants on diving-induced alterations in human cardiovascular function. J Physiol, 2007; 578(3): p859-870.

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Neville Hart - January 17th, 2017 at 10:09am

After all is said, i have been diving for over 30 years having done Trimix diving etc. My son(Diving for 20years) and i frequently dive Sodwana and do 2 to 3 dives a day over a weekend, diving to our computor sit time and same mix Nitrox. I am 67 years and my son 40 years, both reasonably fit, and have both commented that after 2 dives on Nitrox we both are not as fatigued as doing 2 dives on air. We are both regular divers. Just for the record, as we have done the same dive sites and depths on both air and Nitrox. Thank you and we do enjoy your informative articles.


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